Tocris™ Cladribine

Deoxyadenosine analog; pro-apoptotic

Manufacturer: Tocris™ 5292/10

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Catalog No. 52-921-0

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For Research Use Only


    Inhibitors Cladribine
    Purity >99
    Molecular Weight 285.69
    Quantity 10mg
    Product Type Cladribine

    Adenosine deaminase (ADA)-resistant analog of deoxyadenosine. Exhibits anti-leukemic activity; Inhibits cell growth of lymphoid and myeloid neoplasm (IC50 = 20 - 87nM). Pro-apoptotic; induces DNA double-strand breaks. Also inhibits ribonuclease reductase (IC50 = 0.11 - 0.28µM). Displays activity in vitro and in vivo. Orally bioavailable.

    • Chemical Name: (2R,3S,5R)-5-(6-Amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxalan-3-ol
    • Formula: C10H12ClN5O3
    • CAS Number: 4291-63-8
    • Solubility: Soluble to 100mM in DMSO
    • Purity: >99

  • Description & Specifications

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