Deoxyadenosine analog; pro-apoptotic
Manufacturer: Tocris 5292/10
DescriptionAdenosine deaminase (ADA)-resistant analog of deoxyadenosine. Exhibits anti-leukemic activity; Inhibits cell growth of lymphoid and myeloid neoplasm (IC50 = 20 - 87nM). Pro-apoptotic; induces DNA double-strand breaks. Also inhibits ribonuclease reductase (IC50 = 0.11 - 0.28µM). Displays activity in vitro and in vivo. Orally bioavailable.
- Chemical Name: (2R,3S,5R)-5-(6-Amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxalan-3-ol
- Formula: C10H12ClN5O3
- CAS Number: 4291-63-8
- Solubility: Soluble to 100mM in DMSO
- Purity: >99
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