Claudin 14 Polyclonal Antibody, Invitrogen™

Chicken Polyclonal Antibody

Supplier:  Thermo Scientific PA19540

Catalog No. 01-674-423

Description

PA1-9540 detects CLDN14 in human samples. PA1-9540 has been successfully used in Western blot procedures. By Western blot, PA1-9540 detects a 26 kDa protein representing CLDN14. PA1-9540 immunogen is a purified recombinant CLDN14 corresponding to the chromosome 21 gene (Human).

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. Several transcript variants encoding the same protein have been found for this gene.

Specifications

• Antigen: Claudin 14
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CLDN14
• Gene Alias: AI851731; claudin 14; claudin-14; CLDN14; DFNB29; UNQ777/PRO1571
• Host Species: Chicken
• Purification Method: IgY fraction
• Regulatory Status: RUO
• Gene ID (Entrez): 23562
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: O95500
• Gene Symbols: CLDN14
• Immunogen: Purified recombinant CLDN14 corresponding to the chromosome 21 gene (Human).
• Quantity: 500 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgY

Safety and Handling

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