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CLCN1 Rabbit anti-Human, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 185951AP

Catalog No. 50-173-2185


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Description

Description

The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport and maintain cellular volume. CLC1 is highly expressed in skeletal muscle. Mutations in the gene encoding CLC1 lead to myotonia, an inheritable disorder characterized by muscle stiffness and renal salt wasting. CLC2 is highly expressed in the epithelia of several organs including lung, which suggests CLC2 may be a possible therapeutic target for cystic fibrosis. CLC3 expression is particularly abundant in neuronal tissue, while CLC4 expression is evident in skeletal and cardiac muscle as well as brain. Mutations in the gene encoding CLC5 lead to Dents disease, a renal disorder characterized by proteinuria and hypercalciuria. CLC6 and CLC7 are broadly expressed in several tissues including testis, kidney, brain and muscle.
Specifications

Specifications

CLCN1
0.15 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P35523
Chloride channel protein 1, ClC 1, CLC1, CLCN1
Rabbit
IgG
150 μL
-20°C
Primary
1180
ELISA
Unconjugated
CLCN1
Liquid
CLCN1
CLCN1 Fusion Protein Ag13336
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Documents
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