Invitrogen™ CLCNKA Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA592064

Catalog No. PIPA592064

Description

Immunogen sequence: QSCQPSFYDG TIIVKKLPYL PRILGRNIGS HHVRVEHFMN HSITTLAKDT PLEEVVKVVT STDVTEYPLV ESTESQILVG IVQRAQLVQA LQAEPPSRAP GHQQCLQDIL ARGCPTEPVT LTLFSETTLH QAQNLFKLLN LQSLFVTSRG RAVGCVSWVE MKKAISNLTN PPAPK; Positive Samples: LO2, HT-29, A-549; Cellular Location: Membrane, Multi-pass membrane protein.

CLC-KA is a kidney-specific chloride channel that mediates transepithelial chloride transport in the thin ascending limb of the Henle loop in the inner medulla. CLC-KA plays a crucial role in urine concentration. The gene encoding human CLC-KA maps to chromosome 1p36. Mutations in this gene may be associated with nephrogenic diabetes insipidus in those cases where mutations in the vasopressin V2 receptor and the AQP2 water channel are lacking. CLC-KB mediates basolateral chloride ion efflux in the thick ascending limb and in more distal nephron segments. The gene encoding human CLC-KB maps to chromosome 1p36. Mutations in this gene cause type III Barter's syndrome which is characterized by renal salt-wasting and low blood pressure.

Specifications

• Antigen: CLCNKA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CLCNKA
• Gene Alias: C75963; chloride channel K1; chloride channel Ka; Chloride channel protein ClC-Ka; chloride channel, kidney, A; chloride channel, voltage-sensitive Ka; chloride voltage-gated channel Ka; CLCK1; clC-K1; CLCKA; CLC-KA; Clcnk1; Clcnka; hClC-Ka; putative basolateral cTAL chloride channel ClC-Ka
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1187, 12733
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.18 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: P51800, Q9WUB7
• Gene Symbols: CLCNKA
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 470-644 of human CLCNKA (NP_0012440681).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG