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Tocris™ Clemizole hydrochloride

TRPC5 blocker; also H1 antagonist

Manufacturer:  Tocris™ 5371/10

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Catalog No. 53-711-0

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For Research Use Only



TRPC5 channel blocker (IC50 values are 1.1, 6.4, 9.1, 11.3 and 26.5µM for TRPC5, TRPC4, TRPC3, TRPC6 and TRPC7 respectively). Exhibits minimal effect on TRPM3, TRPM8 and TRPV1-4 channels. Also histamine H1 receptor antagonist and anticonvulsant in zebrafish Dravet syndrome model.
  • Chemical Name: 1-[(4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole hydrochloride
  • Formula: C19H20ClN3. HCl
  • CAS Number: 1163-36-6
  • Solubility: Soluble to 20mM in water and to 50mM in DMSO
  • Purity: >99
Description & Specifications


Clemizole hydrochloride
Clemizole hydrochloride
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