Tocris Clemizole hydrochloride
TRPC5 blocker; also H1 antagonist
Manufacturer: Tocris 5371/50
DescriptionTRPC5 channel blocker (IC50 values are 1.1, 6.4, 9.1, 11.3 and 26.5µM for TRPC5, TRPC4, TRPC3, TRPC6 and TRPC7 respectively). Exhibits minimal effect on TRPM3, TRPM8 and TRPV1-4 channels. Also histamine H1 receptor antagonist and anticonvulsant in zebrafish Dravet syndrome model.
- Chemical Name: 1-[(4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole hydrochloride
- Formula: C19H20ClN3. HCl
- CAS Number: 1163-36-6
- Solubility: Soluble to 20mM in water and to 50mM in DMSO
- Purity: >99
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