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CLOCK Mouse anti-Human, Clone: OTI1A6, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526692

Catalog No. PIMA526692


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Description

Description

Circadian rhythmicity is a basic property of phylogenetically diverse organisms which range from animals and plants, to fungi. Regulation of endogenous biological clocks is regulated at the genetic level by a protein-mediated, autoregulatory feed-back loop. In mammals, several genes that encode members of the basic helix-loop helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Transactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-ARNT3 heterodimers bind to E box regulatory elements and stimulate gene transcription. CLOCK has been shown to transactivate the mammalian homolog of Drosophila per. PER, in concert with the product of the mammalian timeless gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL1 transactivation complex.
Specifications

Specifications

CLOCK
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
O15516
KAT13D, bHLHe8, circadian locomoter output cycles kaput protein, circadian locomoter output cycles protein kaput, class E basic helix-loop-helix protein 8
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
9575
Immunohistochemistry (Paraffin), Western Blot
OTI1A6
Unconjugated
CLOCK
Liquid
CLOCK
Human recombit protein fragment corresponding to amino acids 1-285 of CLOCK produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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