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Clofarabine

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Quantity:
5 mg
25 mg
Description
Clofarabine is a deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-α and -ε and potently inhibits ribonucleotide reductase (IC50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.
Specifications
Specifications
Chemical Name or Material | 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine |
CAS | 123318-82-1 |
Assay Percent Range | >99% |
Quantity | 25 mg |
Molecular Formula | C10H11ClFN5O3 |
Formula Weight | Observed MW: 303.68 |
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