Clofarabine, Tocris Bioscience™
Deoxycytidine kinase (dCK) substrate
Supplier: R&D Systems 2600/25
DescriptionClofarabine is a deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-α and -ε and potently inhibits ribonucleotide reductase (IC50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.
|Observed MW: 303.68|
Safety and Handling
Recommended Storage : Store at 4°C
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