Clofarabine, Tocris Bioscience
Deoxycytidine kinase (dCK) substrate
Manufacturer: Tocris Bioscience 2600/25
DescriptionDeoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-α and -ε and potently inhibits ribonucleotide reductase (IC 50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.
|Observed MW: 303.68|
Safety and Handling
Recommended Storage : Desiccate at 4°C
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