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Clofarabine, Tocris Bioscience™

Deoxycytidine kinase (dCK) substrate

Supplier:  R&D Systems 2600/25

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Catalog No. 26-002-5


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Description

Description

Clofarabine is a deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-α and -ε and potently inhibits ribonucleotide reductase (IC50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.
Specifications

Specifications

2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
>99%
C10H11ClFN5O3
123318-82-1
25 mg
Observed MW: 303.68
Safety and Handling

Safety and Handling

Recommended Storage : Store at 4°C

SDS
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