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Clofarabine, Tocris Bioscience™

Deoxycytidine kinase (dCK) substrate

$109.00 - $415.00

Specifications

Assay Percent Range >99%
Formula Weight Observed MW: 303.68
Chemical Name or Material 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
Molecular Formula C10H11ClFN5O3
CAS 123318-82-1
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
26-002-5 View Documents Tocris Bioscience
2600/25
25mg Each for $415.00
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26-005 View Documents Tocris Bioscience
2600/5
5mg Each for $109.00
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Description

Description

Deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-α and -ε and potently inhibits ribonucleotide reductase (IC50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.
Specifications

Specifications

>99%
2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
123318-82-1
Observed MW: 303.68
C10H11ClFN5O3
Safety and Handling

Safety and Handling

Recommended Storage : Desiccate at 4°C

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