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Clofarabine
Deoxycytidine kinase (dCK) substrate
$165.88 - $620.60
Specifications
| Chemical Name or Material | 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine |
|---|---|
| CAS | 123318-82-1 |
| Assay Percent Range | >99% |
| Molecular Formula | C10H11ClFN5O3 |
| Formula Weight | Observed MW: 303.68 |
Description
Deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-α and -ε and potently inhibits ribonucleotide reductase (IC50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.Specifications
| 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine | |
| >99% | |
| Observed MW: 303.68 |
| 123318-82-1 | |
| C10H11ClFN5O3 |
Safety and Handling
Recommended Storage : Store at 4°C
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