Tocris™ CMPD-1

Non-ATP-competitive p38alpha inhibitor; also tubulin polymerization inhibitor

Manufacturer: Tocris™ 2186/50

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Catalog No. 21-865-0

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    Product Type CMPD-1
    Inhibitors CMPD-1
    Purity >99
    Molecular Weight 349.4
    Quantity 50mg

    Non-ATP-competitive, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-2a) phosphorylation (apparent Ki = 330nM). Does not inhibit p38α-mediated phosphorylation of MBP and ATF-2. Also tubulin polymerization inhibitor. Cytotoxic in glioblastoma cells at concentrations that do not affect the MK2 pathway.

    • Chemical Name: 2'-Fluoro-N-(4-hydroxyphenyl)-[1,1'-biphenyl]-4-butanamide
    • Formula: C22H20FNO2
    • CAS Number: 41179-33-3
    • Solubility: Soluble to 100mM in DMSO and to 100mM in ethanol
    • Purity: >99

  • Description & Specifications

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