Non-ATP-competitive p38alpha inhibitor; also tubulin polymerization inhibitor
Manufacturer: Tocris 2186/50
DescriptionNon-ATP-competitive, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-2a) phosphorylation (apparent Ki = 330nM). Does not inhibit p38α-mediated phosphorylation of MBP and ATF-2. Also tubulin polymerization inhibitor. Cytotoxic in glioblastoma cells at concentrations that do not affect the MK2 pathway.
- Chemical Name: 2'-Fluoro-N-(4-hydroxyphenyl)-[1,1'-biphenyl]-4-butanamide
- Formula: C22H20FNO2
- CAS Number: 41179-33-3
- Solubility: Soluble to 100mM in DMSO and to 100mM in ethanol
- Purity: >99
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