Non-ATP-competitive p38alpha inhibitor; also tubulin polymerization inhibitor
Manufacturer: Tocris 2186/10
DescriptionNon-ATP-competitive, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-2a) phosphorylation (apparent Ki = 330nM). Does not inhibit p38α-mediated phosphorylation of MBP and ATF-2. Also tubulin polymerization inhibitor. Cytotoxic in glioblastoma cells at concentrations that do not affect the MK2 pathway.
- Chemical Name: 2'-Fluoro-N-(4-hydroxyphenyl)-[1,1'-biphenyl]-4-butanamide
- Formula: C22H20FNO2
- CAS Number: 41179-33-3
- Solubility: Soluble to 100mM in DMSO and to 100mM in ethanol
- Purity: >99
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok