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CNOT4 Monoclonal Antibody (OTI4C7), TrueMAB™, OriGene
Mouse Monoclonal Antibody
Supplier: OriGene TA504475
Description
CNOT4 is a 575 amino acid protein with E3 ubiquitin ligase activity, mainly involved in protein modification and protein ubiquitination. It contains a ring type zinc finger domain of the C4C4 type, an RNA recognition motif and a bipartite nuclear localization signal.Studies show that CNOT4 is a component of the CCR4-NOT (CAF1) core complex that functions as general transcription regulation complex and has both a positive as well as a negative effect on the transcription of multiple functionally unrelated genes, thus controls gene expression. CNOT4 interacts with CNOT1 via C-terminus and with E2 ubiquitin ligases via C4C4 RING domain. Reports suggest that CNOT4 gets phosphorylated in response to DNA damage on consensus sites recognized by ATM and ATR.Specifications
CNOT4 | |
Monoclonal | |
0.56 mg/mL | |
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
O95628 | |
CNOT4 | |
Human recombit protein fragment corresponding to amino acids 190-455 of human CNOT4 produced in E.coli. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG1 |
Western Blot | |
OTI4C7 | |
Unconjugated | |
CNOT4 | |
CLONE243, NOT4, NOT4H | |
Mouse | |
Affinity Chromatography | |
RUO | |
4850 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
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