CNOT4 Mouse anti-Human, Clone: OTI4C7, liquid, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene TA504475
DescriptionCNOT4 is a 575 amino acid protein with E3 ubiquitin ligase activity, mainly involved in protein modification and protein ubiquitination. It contains a ring type zinc finger domain of the C4C4 type, an RNA recognition motif and a bipartite nuclear localization signal.Studies show that CNOT4 is a component of the CCR4-NOT (CAF1) core complex that functions as general transcription regulation complex and has both a positive as well as a negative effect on the transcription of multiple functionally unrelated genes, thus controls gene expression. CNOT4 interacts with CNOT1 via C-terminus and with E2 ubiquitin ligases via C4C4 RING domain. Reports suggest that CNOT4 gets phosphorylated in response to DNA damage on consensus sites recognized by ATM and ATR.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide|
|CLONE243, NOT4, NOT4H|
|-20° C, Avoid Freeze/Thaw Cycles|
|Human recombit protein fragment corresponding to amino acids 190-455 of human CNOT4 produced in E.coli.|
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