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CNOT4 Mouse anti-Human, Clone: OTI3D11, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525914

Catalog No. PIMA525914


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Description

Description

CNOT4 is a 575 amino acid protein with E3 ubiquitin ligase activity, mainly involved in protein modification and protein ubiquitination. It contains a ring type zinc finger domain of the C4C4 type, an RNA recognition motif and a bipartite nuclear localization signal. Studies show that CNOT4 is a component of the CCR4-NOT (CAF1) core complex that functions as general transcription regulation complex and has both a positive as well as a negative effect on the transcription of multiple functionally unrelated genes, thus controls gene expression. CNOT4 interacts with CNOT1 via C-terminus and with E2 ubiquitin ligases via C4C4 RING domain. Reports suggest that CNOT4 gets phosphorylated in response to DNA damage on consensus sites recognized by ATM and ATR.
Specifications

Specifications

CNOT4
Monoclonal
0.81 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
O95628
CLONE243, NOT4, NOT4H, CCR4-NOT transcription complex subunit 4, CCR4-associated factor 4, E3 ubiquitin-protein ligase CNOT4, NOT4 (negative regulator of transcription 4, yeast) homolog, potential transcriptional repressor NOT4Hp
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
4850
Flow Cytometry, Western Blot
OTI3D11
Unconjugated
CNOT4
Liquid
CNOT4
Human recombit protein fragment corresponding to ammino acids 190-455 of CNOT4 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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