Invitrogen™ CNOT6L Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5114256

Catalog No. PIPA5114256

Description

Immunogen sequence: AKIMSEQERK HVDGCAIFFK TEKFTLVQKH TVEFNQVAMA NSDGSEAMLN For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. Predicted homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%.

Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence. [UniProt].

Specifications

• Antigen: CNOT6L
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CNOT6L
• Gene Alias: Carbon catabolite repressor protein 4 homolog B; CCR4b; CCR4-NOT transcription complex subunit 6 like; CCR4-NOT transcription complex subunit 6-like; CCR4-NOT transcription complex, subunit 6-like; CNOT6L
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 246175
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q96LI5
• Gene Symbols: CNOT6L
• Immunogen: Synthetic peptide directed towards the middle region of Human CNOT6L.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG