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Cofilin Mouse anti-Human, Mouse, Rat, Clone: GT217, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527737

Catalog No. PIMA527737


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Description

Description

Positive Control: 293T, A431, HeLa, HepG2, PC-12, Rat-2, Neuro2A, C8D30, NIH-3T3, Raw264.7, C2C12 Predicted Reactivity: Pig (99%), Sheep (99%), Rhesus Monkey (99%), Bovine (99%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

The protein encoded by Cofilin 1 can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.
Specifications

Specifications

Cofilin
Monoclonal
1.0 mg/ml
PBS with no preservative
P18760, P23528, P45592
CFL1, CFL, cofilin 1 (non-muscle)
Mouse
IgG2b
100 μl
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
1072, 12631, 29271
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
GT217
Unconjugated
CFL1
Liquid
CFL1
Recombit protein encompassing a sequence within the center region of human Cofilin 1. The exact sequence is proprietary.
Protein A
RUO
Antibody
Monoclonal
Human, Mouse, Rat
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