Invitrogen™ Connexin 45 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596561

Catalog No. PIPA596561

Description

Immunogen sequence: IWEMLHLGFG TIRDSLNSKR RELEDPGAYN YPFTWNTPSA PPGYNIAVKP DQIQYTELSN AKIAYKQNKA NTAQEQQYGS HEENLPADLE ALQREIRMAQ ERLDLAVQAY SHQNNPHGPR EKKAKVGSKA GSNKSTASSK SGDGKTSVWI; Positive Samples: SW480, 293T, Mouse heart; Cellular Location: Cell junction, Cell membrane, Multi-pass membrane protein, gap junction.

Gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell closely packed transmembrane channels. Proteins, called connexins, purified from fractions of enriched gap junctions from different tissues differ. Connexins are designated by their molecular mass. Another system of nomenclature divides gap junction proteins into 2 categories, alpha and beta, according to sequence similarities at the nucleotide and amino acid levels. For example, CX43 is designated alpha-1 gap junction protein, whereas CX32 and CX26 are called beta-1 and beta-2 gap junction proteins, respectively. This nomenclature emphasizes that CX32 and CX26 are more homologous to each other than either of them is to CX43. Connexins have four transmembrane, three intracellular, and two extracellular regions. Different tissues express different connexins, though tissue specificities overlap, and a given tissue or cell can express several different connexins. Developmental regulation of at least some of the connexin genes has been found. Embryo implantation is regulated in part by temporally changing patterns of expression of connexins in the embryo and the maternal decidua.

Specifications

• Antigen: Connexin 45
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GJC1
• Gene Alias: C130009G16Rik; Cnx45; connexin 45; connexin-45; CTC-296K1.4; CX45; Cxn-45; Gap junction alpha-7 protein; gap junction channel protein connexin 45; gap junction gamma-1 protein; gap junction membrane channel protein alpha 7; gap junction protein gamma 1; gap junction protein, gamma 1; gap junction protein, gamma 1, 45kDa; Gja7; Gja-7; GJC1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10052, 14615
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.93 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P28229, P36383
• Gene Symbols: GJC1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 247-396 of human GJC1 (NP_0054882).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov