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COP1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA548171

Catalog No. PA548171

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Caspase inhibitor. Acts as a regulator of procaspase- 1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro- inflammatory cytokine response. Also able to inhibit CASP1- mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.
Specifications

Specifications

COP1
Polyclonal
Unconjugated
CARD16
Liquid
CARD16
KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human COP1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Flow Cytometry, Western Blot
0.35 mg/mL
PBS with 0.09% sodium azide
Q5EG05
Caspase recruitment domain-containing protein 16, Caspase recruitment domain-only protein 1, CARD-only protein 1, Caspase-1 inhibitor COP, Pseudo interleukin-1 beta converting enzyme, Pseudo-ICE, Pseudo-IL1B-converting enzyme, CARD16, COP, COP1
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
114769
Documents
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