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Coronin 1A Mouse anti-Human, Clone: OTI1A5, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525176

Catalog No. PIMA525176


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Description

Description

Highly conserved coronin family of proteins/actin regulators from WD-repeat superfamily were originally identified in Dictyostelium, wherein, coronin deletions were observed to affect actin-dependent processes, such as phagocytosis, cell motility, and cytokinesis. Coronin-1A (Coro1A) belongs to Type I coronins, almost exclusively expressed in hematopoietic lineages, and plays a key role during T lymphocyte activation, migration, survival, and calcium signaling. Moreover, Coronin-1A has been documented to be dispensable for actin-dependent functions in macrophages. Coro1a-deficient mice have reduced peripheral T cells due to both an impaired survival of naive cells and migrational defects. Both CD4+ and CD8+ T cell subsets are decreased in the periphery of Coro1a-/- mice while thymic cellularity and subpopulations are similar to those observed in wild-type mice. A nonsense mutation in Coro1a has been shown to protect against systemic lupus in a mouse model. Moreover, it has shown that Coro1a is mutated in a thymic egress-deficient mouse strain, but also in a patient with severe combined immunodeficiency (SCID).
Specifications

Specifications

Coronin 1A
Monoclonal
0.8 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P31146
CORO1A; Coronin 1; TACO; p57; CLABP; HCORO1; CLIPINA; Clabp TACO; coronin, actin binding protein, 1A; coronin-1; coronin, actin-binding, 1A; coronin, actin-binding protein, 1A; FLJ41407; MGC117380;
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
11151
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot
OTI1A5
Unconjugated
CORO1A
Liquid
CORO1A
Full length human recombit protein of CORO1A produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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