Coronin 1A Mouse anti-Human, Clone: OTI1A5, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA525176
DescriptionHighly conserved coronin family of proteins/actin regulators from WD-repeat superfamily were originally identified in Dictyostelium, wherein, coronin deletions were observed to affect actin-dependent processes, such as phagocytosis, cell motility, and cytokinesis. Coronin-1A (Coro1A) belongs to Type I coronins, almost exclusively expressed in hematopoietic lineages, and plays a key role during T lymphocyte activation, migration, survival, and calcium signaling. Moreover, Coronin-1A has been documented to be dispensable for actin-dependent functions in macrophages. Coro1a-deficient mice have reduced peripheral T cells due to both an impaired survival of naive cells and migrational defects. Both CD4+ and CD8+ T cell subsets are decreased in the periphery of Coro1a-/- mice while thymic cellularity and subpopulations are similar to those observed in wild-type mice. A nonsense mutation in Coro1a has been shown to protect against systemic lupus in a mouse model. Moreover, it has shown that Coro1a is mutated in a thymic egress-deficient mouse strain, but also in a patient with severe combined immunodeficiency (SCID).
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|CORO1A; Coronin 1; TACO; p57; CLABP; HCORO1; CLIPINA; Clabp TACO; coronin, actin binding protein, 1A; coronin-1; coronin, actin-binding, 1A; coronin, actin-binding protein, 1A; FLJ41407; MGC117380;|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot|
|Full length human recombit protein of CORO1A produced in HEK293T cell|
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