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Tocris Bioscience™ CP 724714

Potent and selective ErbB2 inhibitor

$209.00 - $879.00

Specifications

Chemical Name or Material 2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide
Molecular Formula C27H27N5O3
CAS 383432-38-0
Product Type Target: EGF Receptor Inhibitors
Formula Weight 469.53
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
59-731-0 View Documents Tocris Bioscience™
5973/10
10mg Each for $209.00
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59-735-0 View Documents Tocris Bioscience™
5973/50
50mg Each for $879.00
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Description

Description

Potent and selective ErbB2 inhibitor (IC50 = 10 nM). Exhibits 500-1000-fold selectivity for ErbB2 over ErbB1 and other related RTKs. Induces G1 cell cycle arrest in an ErbB2-overexpressing human cancer cell line. Promotes tumor apoptosis. Induces tumor regression in a human tumor xenograft model. Displays no apparent toxic effect on cardiac tissue.
Specifications

Specifications

2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide
383432-38-0
469.53
C27H27N5O3
Target: EGF Receptor Inhibitors
Safety and Handling

Safety and Handling

Recommended Storage : Store at −20°C

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