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CD21 Mouse anti-Human, PE, Clone: LT21, Invitrogen™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen A15773

Catalog No. 50-113-7757



Description

Description

CD21 (complement receptor 2, CR2, C3D receptor, EBV receptor) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintece of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to follicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands. CD21 functions as receptor for C3d, C3dg and iC3b complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation. Genetic variations in the CD21 gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively, spliced transcript variants encoding different isoforms of CD21 have been found.
Specifications

Specifications

CD21
Monoclonal
PE
CR2
Liquid
CR2
Human CD21
Purified
RUO
Antibody
Monoclonal
Human
Flow Cytometry
LT21
PBS with 0.2% BSA and 15mM sodium azide
P20023
EBV receptor, complement C3d receptor, complement receptor type 2, epstein-Barr virus receptor
Mouse
IgG1
100 tests
4° C
Primary
1380
Documents
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