Tocris™ CRID3 sodium salt

Potent NLRP3 inflammasome inhibitor; inhibits IL-1beta production

Manufacturer: Tocris™ 5479/50

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Catalog No. 54-795-0

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For Research Use Only


    Description CRID3 sodium salt
    Molecular Weight 426.46
    Purity >97
    Quantity 50mg
    Product Type CRID3 sodium salt

    Potent NLRP3 inflammasome inhibitor; inhibits IL-1β production (IC50 = 7.5nM). Selective for NLRP3 inflammasome over NLRC4 inflammasome and Toll-like receptor signaling. Reduces severity of experimental autoimmune encephalomyelitis in mice. Also glutathione S-transferase omega 1 inhibitor. Orally bioavailable.

    • Chemical Name: N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt
    • Formula: C20H23N2NaO5S
    • CAS Number: 256373-96-3
    • Solubility: Soluble to 100mM in DMSO and to 50mM in ethanol
    • Purity: >97

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