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CRY2 Mouse anti-Human, Clone: OTI1H5, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525543

Catalog No. PIMA525543


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Description

Description

Various biochemical, physiological and behavioural processes display circadian rhythms controlled by an internal biological clock. The central """"gears"""" driving this clock appear to be composed of an autoregulatory transcription/posttranslation-based feedback loop. Cryptochrome 1 (CRY1) and 2 (CRY2) are DNA-binding flavoproteins that bear some homology to blue-light receptors and photolyases. In Drosophila, CRY is a photoreceptor for the circadian clock where it binds to the clock component TIM in a light-dependent fashion and blocks its function. Mammalian CRY1 and CRY2 function via light-independent interactions with circadian genes CLOCK and BMAL1, as well as with PER1, PER2, and TIM. They seem to act as light-independent components of the circadian clock and likely regulate Per1 transcriptional cycling via interactions with both the activator and its feedback inhibitors. Mutant mice not expressing the Cry1 or Cry2 protein display accelerated and delayed periodicity of locomotor activity, respectively. It appears that the combination of both proteins working together is essential to synchronize the organism to circadian phases. A critical balance between Cry1 and Cry2 is required for proper clock function; in complete darkness, double-mutant mice present with instantaneous arrhythmicity, indicating the absence of an internal circadian clock.
Specifications

Specifications

CRY2
Monoclonal
0.78 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q49AN0
Cryptochrome-2; CRY2; KIAA0658
Mouse
IgG2a
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
1408
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI1H5
Unconjugated
CRY2
Liquid
CRY2
Full length human recombit protein of CRY2 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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