Alpha A Crystallin Mouse anti-Human, Clone: OTI3B12, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526164
DescriptionCrystallins are the major proteins of the vertebrate eye lens, where they maintain the transparency and refractive index of the lens. Crystallins are divided into alpha, beta and gamma families, and the beta- and gamma-crystallins also compose a superfamily. Crystallins usually contain seven distinct protein regions, including four homologous motifs, a connecting peptide, and N- and C-terminal extensions. alpha-crystallins consist of three gene products, alphaA, alphaB and alphaC-crystallin, which are members of the small heat shock protein family (HSP 20). They are induced by heat shock, and act as molecular chaperones by holding denatured proteins in large soluble aggregates. However, unlike other molecular chaperones, alpha-crystallins do not renature these proteins. Expression of alphaA-crystallin is restricted to the lens. Defects in this gene cause autosomal domit congenital cataracts (ADCC). The human alphaB-crystallin gene product is expressed in many tissues, including lens, heart and skeletal muscle. Elevated expression of alphaB-crystallin is associated with many neurological diseases, and a missense mutation in this gene has co-segregated in a family with a Desmin-related myopathy.
|Alpha A Crystallin|
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|Acry 1; Alpha crystallin A chain; Alpha-crystallin A chain; CRYA 1; CRYA1; CRYAA; CRYAA_HUMAN; Crystallin Alpha 1; Crystallin alpha A; Heat shock protein beta 4; Heat shock protein beta-4; HSPB 4; HspB4; short form; Zonular Central Nuclear Cataract;|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of CRYAA produced in HEK293T cell|
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