STAT3 inhibitor. Also displays multiple other activities
Manufacturer: Tocris 3713/10
DescriptionMajor tanshinone isolated from Salvia miltiorrhiza that exhibits multiple activities. Exhibits antitumor activity via inhibition STAT3 activity (IC50 = 4.6µM). Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also improves cognitive impairment in Alzheimer's disease transgenic mice by inhibition of acetylcholinesterase (IC50 = 4.09µM) and reduction in Aβ peptide generation.
- Chemical Name: 1,2,6,7,8,9-Hexahydro-1,6,6-trimethyl[1,2-b]furan-10,11-dione
- Formula: C19H20O3
- CAS Number: 35825-57-1
- Solubility: Soluble to 10mM in DMSO
- Purity: >98