CSNK1E Mouse anti-Human, Clone: OTI5C9, liquid, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene TA803800

Catalog No. 50-167-9927

Description

Casein kinases are a group of ubiquitous Ser/Thr kinases that phosphorylate key regulatory proteins involved in the control of cell differentiation, proliferation, chromosome segregation, circadian rhythms, and metabolic pathways. CK1 family members share a highly conserved kinase domain but differ in their variable N-and C-terminal domains. Mammals have seven family members: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. They all share at least 50% amino acid identity within the protein kinase catalytic domain. CK1 isoforms exclusively use ATP as phosphate donor and are generally co-factor independent. Casein kinase I epsilon is a Wnt-regulated kinase, and regulated phosphorylation of Dvl allows fine tuning of the Wnt-b-catenin signaling pathway. CKIe positively regulates Akt possibly by inhibiting PP2A. CKIe play an important role in neurodegenerative diseases.

Specifications

• Antigen: CSNK1E
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P49674
• Gene Symbols: CSNK1E
• Immunogen: Human recombit protein fragment corresponding to amino acids 153-416 of human CSNK1E produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Western Blot
• Clone: OTI5C9
• Conjugate: Unconjugated
• Gene: CSNK1E
• Gene Alias: CKIepsilon, HCKIE
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1454
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid