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CTDSP1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550941

Catalog No. PA550941


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Description

Description

CTDSP1 / NIF3 Polyclonal Antibody detects endogenous levels of CTDSP1 / NIF3 protein.

CTDSP1 is a class 2C phosphatase with activity dependent on the conserved DxD motif. Expression of CTDSP1 inhibited activated transcription from several promoter-reporter gene constructs, but expression of a mutant lacking phosphatase activity enhanced transcription. Neuronal gene transcription is repressed in nonneuronal cells by the repressor element-1 (RE1)-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF; 600571) complex. REST/NRSF recruits SCPs to neuronal genes that contain RE1 elements, leading to neuronal gene silencing in nonneuronal cells. Phosphatase-inactive forms of SCP interfere with REST/NRSF function and promote neuronal differentiation of P19 stem cells. Likewise, small interfering RNA directed to the single Drosophila SCP unmasks neuronal gene expression in S2 cells. Thus, SCP activity is an evolutionarily conserved transcriptional regulator that acts globally to silence neuronal genes.
Specifications

Specifications

CTDSP1
Polyclonal
Unconjugated
CTDSP1
Liquid
CTDSP1
Synthesized peptide derived from the N-terminal region of human CTDSP1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
ELISA, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
Q9GZU7, P58466
NIF3, NLIIF, SCP1
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
227292, 363249, 58190
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