CtIP Monoclonal Antibody (14-1), Active Motif™

Mouse Monoclonal Antibody

Supplier:  Active Motif 61142

Catalog No. 50-199-3179

Description

CtIP, a 125 kD protein, was originally found interacting with a transcription repressor, CtBP, through the PLDLS motif (CtBP-Interacting Protein) thus suggested a role in transcription. Studies have shown that CtIP also interacts with BRCA1 protein through the c-terminus BRCT domains also suggested that CtIP is a potential tumor suppressor. This CtIP-BRCA1 interaction can be disrupted by DNA damaging agents including UV or gamma-irradiation. Li et al (Nature 406, 210 - 215 (2000)) have shown that ATM phosphorylates CtIP at serine residues 664 and 745, and mutation of these sites abrogates the dissociation of BRCA1 from CtIP, resulting in persistent repression of BRCA1-dependent induction of GADD45 upon ionizing radiation.

Specifications

• Antigen: CtIP
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
• Gene Accession No.: Q99708
• Gene Symbols: Rbbp8
• Immunogen: This CtIP antibody was raised against a recombinant protein corresponding to amino acid residues 620-897 of human CtIP.
• Quantity: 10 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ChIP Assay, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
• Clone: 14-1
• Conjugate: Unconjugated
• Gene: Rbbp8
• Gene Alias: 9930104E21Rik; COM1; CtBP-interacting protein; Ctip; DNA endonuclease RBBP8; JWDS; RB binding protein 8, endonuclease; Rbbp8; RBBP-8; retinoblastoma binding protein 8; Retinoblastoma-binding protein 8; Retinoblastoma-interacting protein and myosin-like; RGD1308872; RIM; SAE2; SCKL2; Sporulation in the absence of SPO11 protein 2 homolog
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 5932
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid