CTNNB1 (phospho S715) Rabbit anti-Human, Mouse, Rabbit, Polyclonal , Abnova™

Rabbit polyclonal antibody raised against synthetic phosphopeptide of human CTNNB1.

Supplier:  Abnova Corporation PAB29626

Catalog No. 89-956-745

Description

Beta-catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the 'contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete.[supplied by OMIM]

Specifications

• Antigen: CTNNB1 (phospho S715)
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic phosphopeptide of human CTNNB1.
• Formulation: In PBS (without Mg2+ and Ca2+), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
• Gene Symbols: CTNNB1
• Immunogen: A synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S715 of human CTNNB1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Test Specificity: CTNNB1 (phospho S715) polyclonal antibody detects endogenous level of CTNNB1 only when phosphorylated at serine 715.
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: Immunohistochemistry (PFA fixed), Western Blot
• Conjugate: Unconjugated
• Dilution: Immunohistochemistry (1:50-1:100) Western Blot (1:500-1:1000) The optimal working dilution should be determined by the end user.
• Gene Alias: CTNNB/DKFZp686D02253/FLJ25606/FLJ37923
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1499
• Target Species: Human, Mouse, Rabbit
• Form: Liquid