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CUEDC2 Mouse anti-Human, Clone: OTI2H6, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526487

Catalog No. PIMA526487


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Description

Description

The CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain is an evolutionarily conserved, ~40 amino acid monoubiquitin-binding domain that mediates intramolecular monoubiquitylation. CUE domains are present in eukaryotic proteins that are involved in ubiquitination and protein trafficking pathways and may be required for ubiquitination of the proteins in which they are found. CUEDC2 (CUE domain-containing protein 2) was found through a yeast two-hybrid screening as a protein that interacts with the progesterone receptor (PR) and promotes progesterone-induced PR degradation by the ubiquitin-proteasome pathway. CUEDC2 also decreases the sumoylation of PR. CUEDC2 has also been found to interact with IKK-alpha and IKK-beta and decrease the activation of NF-kappa-B by decreasing the activation of IKK.
Specifications

Specifications

CUEDC2
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q9H467
HOYS6, C10orf66, bA18I14.5; CUE domain-containing protein 2
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
79004
Western Blot
OTI2H6
Unconjugated
CUEDC2
Liquid
CUEDC2
Full length human recombit protein of CUEDC2 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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