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CUGBP1 Mouse anti-Human, Clone: OTI5B8, liquid, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner TA500951S

Catalog No. 50-167-2093


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Description

Description

Myotonic dystrophy (MD) is an autosomal domit neuromuscular disease that is associated with a (CTG)n repeat expansion in the 3 ft.-untranslated region of the myotonin protein kinase (Mt-PK) gene. A (CUG) n oligonucleotides triplet repeat pre-mRNA/mRNA binding protein may play an important role in DM pathogenesis. HeLa cell protein, CUG-BP1, has been purified based upon its ability to bind specifically to (CUG) 8 oligonucleotides in vitro. CUG-BP1 is the major (CUG) 8 binding activity in normal cells. CUG-BP1 has been identified as isoforms of a novel heterogeneous nuclear ribonucleoprotein (hnRNP), hNab50. The CUG-BP/hNab50 protein is localized predomitly in the nucleus and is associated with polyadenylated RNAs in vivo. In vitro RNA-binding/photocrosslinking studies demonstrate that CUG-BP/hNab50 binds to RNAs containing the Mt-PK 3-UTR. The (CUG) n repeat region in Mt-PK mRNA is a binding site for CUG-BP/hNab50 in vivo, and triplet repeat expansion leads to sequestration of this hnRNP on mutant Mt-PK transcripts.
Specifications

Specifications

CUGBP1
Monoclonal
0.99 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Q92879
BRUNOL2, CUG-BP, CUGBP, CUGBP1, EDEN-BP, NAB50, NAPOR, hNab50
Mouse
IgG2b
30 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
10658
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI5B8
Unconjugated
CELF1
Liquid
CELF1
Full length human recombit protein of human CUGBP1 produced in HEK293T cell.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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