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Cullin 4A Mouse anti-Human, Clone: GT2435, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527795

Catalog No. PIMA527795


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Description

Description

Positive Control: HeLa Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

CUL4a is a core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. In association with RBX1, DDB1 and DDB2 is required for histone H3 and histone H4 ubiquitination in response to ultraviolet and may be important for subsequent DNA repair. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitiantion of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9.
Specifications

Specifications

Cullin 4A
Monoclonal
1.0 mg/mL
PBS with no preservative
Q13619
CUL-4A, CUL4A, Cullin 4a
Mouse
IgG2b
100 μl
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
8451
Immunocytochemistry, Immunofluorescence, Western Blot
GT2435
Unconjugated
CUL4A
Liquid
CUL4A
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Cullin 4a. The exact sequence is proprietary.
Protein A
RUO
Antibody
Monoclonal
Human
Documents
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