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Cullin 4B Mouse anti-Canine, Human, Mouse, Non-human primate, Rat, Clone: OTI7F8, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526436

Catalog No. PIMA526436


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Description

Description

Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8.
Specifications

Specifications

Cullin 4B
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q13620, A2A432
MRXHF2, MRXS15, MRXSC, SFM2, CUL-4B, cullin-4B
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
302502, 492102, 696410, 72584, 8450
Western Blot
OTI7F8
Unconjugated
CUL4B
Liquid
CUL4B
Human recombit protein fragment corresponding to amino acids 1-300 of CUL4B produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Canine, Human, Mouse, Non-human primate, Rat
Documents
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