Cutaneous Lymphocyte Antigen (CLA) Rat anti-Human, Clone: HECA-452, eBioscience™ Invitrogen™
Rat Monoclonal Antibody
This HECA-452 MAb reacts with human Cutaneous Lymphocyte Antigen (CLA). This cell surface glycoprotein is most highly expressed on T cells in the skin. Nevertheless, CLA can also be detected on some peripheral T and NK cells, as well as monocytes, neutrophils and CD1a+ dendritic cells. Studies have determined that this antibody recognizes sialofucosylated glycans and sialyl Lewis x (sLex). CLA, which binds E-selectin and endothelial cell-leukocyte adhesion molecule 1 (ELAM-1), is involved in T lymphocyte infiltration and adhesion at cutaneous sites of inflammation. The HECA-452 antibody has been reported to inhibit sLex binding to E-selectin; however, this property is still under debate in the literature.Cutaneous Lymphocyte Antigen (CLA) Monoclonal antibody specifically detects Cutaneous Lymphocyte Antigen (CLA) in Human samples. It is validated for Flow Cytometry, Functional Assay, Immunohistochemistry (Paraffin), Western Blot
|Cutaneous Lymphocyte Antigen (CLA)|
|Flow Cytometry, Functional Assay, Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.09% sodium azide; pH 7.2|
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