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Cutaneous Lymphocyte Antigen (CLA) Rat anti-Human, Clone: HECA-452, eBioscience™ Invitrogen™ Non-distribution product as customer accommodation.

Rat Monoclonal Antibody

Catalog No. 14-985-737


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Description

Description

This HECA-452 MAb reacts with human Cutaneous Lymphocyte Antigen (CLA). This cell surface glycoprotein is most highly expressed on T cells in the skin. Nevertheless, CLA can also be detected on some peripheral T and NK cells, as well as monocytes, neutrophils and CD1a+ dendritic cells. Studies have determined that this antibody recognizes sialofucosylated glycans and sialyl Lewis x (sLex). CLA, which binds E-selectin and endothelial cell-leukocyte adhesion molecule 1 (ELAM-1), is involved in T lymphocyte infiltration and adhesion at cutaneous sites of inflammation. The HECA-452 antibody has been reported to inhibit sLex binding to E-selectin; however, this property is still under debate in the literature.

Cutaneous Lymphocyte Antigen (CLA) Monoclonal antibody specifically detects Cutaneous Lymphocyte Antigen (CLA) in Human samples. It is validated for Flow Cytometry, Functional Assay, Immunohistochemistry (Paraffin), Western Blot
Specifications

Specifications

Cutaneous Lymphocyte Antigen (CLA)
Flow Cytometry, Functional Assay, Immunohistochemistry (Paraffin), Western Blot
HECA-452
Unconjugated
CLA
IgM, kappa
2 mg
4° C
Primary
Human
Liquid
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
SDS
Documents
Product Certifications
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