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Cyclin B1 Rabbit anti-Human, Mouse, Unconjugated, Clone: ARC0474, Invitrogen™

Rabbit Monoclonal Antibody

Manufacturer:  Invitrogen MA535219

Catalog No. PIMA535219


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Description

Description

Cyclins bind to and regulate the activity of the Cyclin dependent protein kinases (CDKs). Cyclin B1 or CCNB1 is a regulatory protein involved in mitosis. It is essential for the control of the cell cycle at the G2/M transition. Cyclin B1 complexes with p34 (cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. Cyclin B1 is not ubiquitinated during G2/M phase, resulting in its steady accumulation during G2 phase, followed by abrupt APC dependent destruction at the end of mitosis. Destruction of Cyclin B1 is required for cell cycle progression. Cyclin B1 is overexpressed in various cancers, including breast, prostate, and non-small cell lung cancer.
Specifications

Specifications

Cyclin B1
ARC0474
PBS with 50% glycerol and 0.2% sodium azide; pH 7.3
P14635, P24860
Ccn-2; CCNB; CCNB1; Ccnb1-rs1; Ccnb1-rs13; Cycb; Cycb1; Cycb1-rs1; Cycb-4; Cycb-5; G2/mitotic-specific cyclin-B1; I79_013589; OTTHUMP00000221981; OTTHUMP00000223023
Rabbit
IgG
100 μL
-20°C, Avoid Freeze/Thaw Cycles
Primary
268697, 891
Western Blot
Unconjugated
Ccnb1
Liquid
Ccnb1
A synthesized peptide derived from human Cyclin B1
Protein A
RUO
Antibody
Monoclonal
Human, Mouse
SDS
Documents
Product Certifications
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