Cyclin D1 Mouse anti-Human, Mouse, Rat, Primate, Alexa Fluor 750, Clone: DCS-6, Novus Biologicals
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP233138AF750
DescriptionCyclin D1 Monoclonal antibody specifically detects Cyclin D1 in Human, Mouse, Rat, Primate samples. It is validated for ELISA.
|Human recombinant full length Cyclin D1 protein was used as immunogen to generate this antibody.|
|Protein G purified|
|Cancer, Cell Cycle and Replication, Core ESC Like Genes, mTOR Pathway, Stem Cell Markers, Wnt Signaling Pathway|
|Human, Mouse, Primate, Rat|
|Alexa Fluor™ 750|
|50 mM sodium borate with 0.05% sodium azide|
|B-cell lymphoma 1 protein, BCL-1, BCL-1 oncogene, BCL1D11S287E, cyclin D1, cyclin D1 (PRAD1: parathyroid adenomatosis 1), G1/S-specific cyclin D1, G1/S-specific cyclin-D1, PRAD1 oncogene, PRAD1B-cell CLL/lymphoma 1, U21B31|
|Store at 4°C in the dark.|
|Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.|
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