Epredia™ Lab Vision™ Cyclin E Ab-5, Mouse Monoclonal Antibody

Obtain accurate, reproducible results in immunohistochemistry and immunoprecipitation experiments with Epredia™ Cyclin E Ab-5, Mouse Monoclonal Antibody.

Supplier:  Epredia™ MS1060S0

Catalog No. MS1060S0

Description

Cyclin E is a regulatory subunit of cdk-2 and controls G1/S transition during the mammalian cell cycle. Multiple isoforms of cyclin E are expressed only in tumors but not in the normal tissues, suggesting a post-transcriptional regulation of cyclin E. In vitro analyses indicated that these truncated variant isoforms of cyclin E are able to phosphorylate histone H1. Alterations in cyclin E protein have been implicated as indicators of worse prognosis in various cancers.

Host Species: Mouse

Clone: 13A3

Isotype: IgG2a/κ

Species Reactivity: Human. Others not known.

Epitope: Not determined

Immunogen: Recombinant human cyclin E protein

Molecular Weight: Doublet of 50 kDa and a single band of 42 kDa

Positive Control: SKBR3 and LS174T cells; Breast CA or placenta

Cellular Localization: Nuclear

Recommended for:

• Immunohistochemistry (Formalin/paraffin)
• Immunoprecipitation (Native and Denatured)

Note:

USA: RUO; Int'l: RUO

Specifications

• Antigen: Cyclin E Ab-5
• Classification: Monoclonal
• Conjugate: Unconjugated
• Immunogen: Recombinant human cyclin E protein
• Quantity: 100 μL
• Research Discipline: Cell Cycle
• Target Species: Human
• Isotype: IgG2a κ

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation
• Clone: 13A3
• Host Species: Mouse
• Purification Method: SKBR3 and LS174T cells, breast CA or placenta
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Form: Concentrated