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Cyclin L1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549750

Catalog No. PA549750


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Description

Description

The antibody detects endogenous levels of total Cyclin L1 protein.

Cell proliferation is controlled at specific stages of the cell cycle by distinct protein kinase complexes. These complexes consist of a catalytic subunit associating with a specific regulatory subunit to form the active kinase. The cyclins, which include cyclin A, B, C, D, E, F, G, H, I, K, L, T and their related proteins, including Dbf4, comprise the regulatory subunits of these kinase complexes. The controlled activation of the kinase complexes at various intervals of the cell cycle is regulated by the availability of the cyclins to the catalytic subunit. Unlike the catalytic subunit, which is expressed continually, the expression and stability of the regulatory subunit fluctuates depending on the stage of the cell cycle and, thereby, regulates the kinase activity. Cyclin L1 is a ubiquitously expressed nuclear protein that can be detected in higher levels in thymus. In neck and head squamous cell carcinomas, cyclin L1 can be overexpressed and is therefore often considered a proto-oncogene. It interacts with POLR2A, CDC2L and SFRS2. Cyclin L1 plays a role in the mRNA splicing process regulation.
Specifications

Specifications

Cyclin L1
Polyclonal
Unconjugated
CCNL1
Liquid
CCNL1
Synthesized peptide derived from human Cyclin-L1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Q9UK58, Q52KE7, Q9R1Q2
Cyclin-L, CCNL1,
Rabbit
IgG
100 μL
-20°C
Primary
114121, 56706, 57018
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