MilliporeSigma™ Cycloheximide, >98%, Calbiochem™

Description

Antifungal antibiotic. Inhibits protein synthesis in eukaryotes. Interacts directly with translocase and interferes with translocation step.

• Antifungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes
• Interacts directly with translocase enzyme, interfering with the translocation step
• Inhibits cell-free protein synthesis in eukaryotes
• Competitively inhibits hFKBP12 (K_i = 3.4 μM)
• Triggers apoptosis in HL-60 cells, T cell hybridomas, Burkitt’s lymphoma cells, and a variety of other cell types including rodent macrophages
• Inhibits DNA cleavage in rat thymocytes treated with Thapsigargin, methylprednisolone, and Ionomycin
• Rapidly destroyed in alkaline solutions.
• Also available as a 300 mM solution in DMSO

Recommended Storage

+15°C to +30°C, Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.

Specifications

• Packaging: Alu drum
• Quantity: 1 g
• Merck Index: 14, 2728
• Solubility Information: Soluble in Chloroform, Ethanol, and Methanol
• Percent Purity: ≥98%
• Physical Form: Solid
• Chemical Name or Material: Cycloheximide, High Purity
• Grade: By HPLC

Safety and Handling

Hazard Category	Highly Toxic & Carcinogenic / Teratogenic
Hazard Statement	R: 28-40-51/53-61 Very toxic if swallowed. Limited evidence of a carcinogenic effect. Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. May cause harm to the unborn child.
Precautionary Statement	S: 45-53-61 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Avoid exposure - obtain special instructions before use. Avoid release to the environment.
RTECSNumber	MA4375000
storageNote1	Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.
Recommended Storage	+15°C to +30°C; Ok to freeze;