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Cyclophilin B Rabbit anti-Canine, Human, Mouse, Rat, Alexa Fluor® 555, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1027AA555

Catalog No. PIPA1027AAZ

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PA1027AA555 detects cyclophilin B (CyPB) in mouse, rat, canine, and human tissues. The PA1027AA555 immunogen is a synthetic peptide corresponding to residues C(194) G K I E V E K P F A I A K E(208) of human CyPB. This sequence is almost completely conserved between human, mouse, rat, bovine, and chicken. PA1027AA555 immunizing peptide (Cat. No. PEP-058) is available for use in neutralization and control experiments.

Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP ft.s) and those which bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation. Thus, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase ft.s, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins.


Cyclophilin B
Alexa Fluor™ 555
Synthetic peptide corresponding to residues C(194) G K I E V E K P F A I A K E(208) of human CyPB
Antigen affinity chromatography
Canine, Human, Mouse, Rat
1 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.4
P23284, P24369, P24368
AI844835, SCYLP, Cphn-2, CypB, OI9, Scylp, Cphn2, AA553318, CyP-20b, CYPB, CYP-S1, AA408962
50 μL
4° C, store in dark, DO NOT FREEZE!
19035, 478337, 5479, 64367
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