CYFIP1/2 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 160111AP
This antibody can recognize both CYFIP1 and CYFIP2.CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1, 278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|Q5SQX6, Q7L576, Q7TMB8, Q96F07|
|CYFIP2, KIAA1168, p53 inducible protein 121, PIR121|
|20430, 23191, 26999, 76884|
|Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|CYFIP1/2 Fusion Protein Ag8749|
|Antigen Affinity Chromatography|
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