Invitrogen™ CYFIP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA531984

Catalog No. PIPA531984

Description

Recommended positive controls: HeLa, mouse brain, rat brain. Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (93%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA. Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.

Specifications

• Antigen: CYFIP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cyfip1
• Gene Alias: CY; CYFIP; cyfip1; cyfip1 protein; cytoplasmic FMR1 interacting protein 1; cytoplasmic FMR1-interacting protein 1; Cytoplasmic FMR1-interacting protein 1 homolog; cytoplasmic FMRP interacting protein 1; E030028J09Rik; fb15a06; FLJ45151; FMR1-interacting protein 1; KIAA0068; l(7)1Rl; l71Rl; l7Rl1; LOW QUALITY PROTEIN: cytoplasmic FMR1-interacting protein 1; mKIAA0068; P140sra1; p140sra-1; pl-1; selective hybridizing clone; Shyc; Specifically Rac1-associated protein 1; Sra1; Sra-1; Unknown (protein for IMAGE:7152255); wu:fb15a06
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20430, 23191, 308666
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q7L576, Q7TMB8
• Gene Symbols: Cyfip1
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 309 of Human CYFIP1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov