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CYP17A1 Mouse anti-Human, Clone: OTI3F11, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525673

Catalog No. PIMA525673


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Description

Description

CYP17A (17-alpha-hydroxylase/17,20-lyase) is important for the conversion of pregnenolone and progesterone to dehydroepiandrosterone (DHEA) and androstenedione. In this process, it catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. CYP17A1 is crucial during sexual development, both during fetal development and during puberty, and is intracellularly regulated by cAMP levels. Defects in the CYP17A1 gene, which encodes for the protein, may cause adrenal hyperplasia type V (AH-V) which is characterized by hypokalemia and hypertension. Male patients affected by AH-V do not undergo normal sexual differentiation and develop female external genitalia and do not undergo pubertal develoment.
Specifications

Specifications

CYP17A1
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P05093
CYP17A1; cytochrome P450, family 17, subfamily A, polypeptide 1 ; HGNC:2593; CPT7; CYP17; P450C17; S17AH; cytochrome P450, family 17; cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia; cytochrome p450 XVIIA1; steroid 17-alpha-hydroxylase/17,20 lyase; steroid 17-alpha-monooxygenase, 17a-hydroxylase
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
1586
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
OTI3F11
Unconjugated
CYP17A1
Liquid
CYP17A1
Full length human recombit protein of CYP17A1 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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