CYP2A6 Monoclonal Antibody (OTI2A8), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA503827

Catalog No. 50-167-4624

Description

This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6.

Specifications

• Antigen: CYP2A6
• Classification: Monoclonal
• Concentration: 0.86 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P11509
• Gene Symbols: CYP2A6
• Immunogen: Full length human recombit protein of human CYP2A6 produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI2A8
• Conjugate: Unconjugated
• Gene: CYP2A6
• Gene Alias: CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1548
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid