Invitrogen™ CYP2E1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA579131

Catalog No. PIPA579131

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: rat liver tissue, mouse liver tissue. IHC: mouse liver tissue, rat liver tissue.

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.

Specifications

• Antigen: CYP2E1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cyp2e1
• Gene Alias: 4-nitrophenol 2-hydroxylase; CP2E1; CPE1; Cyp2e; Cyp2e1; Cyp2e-1; CYPIIE1; cytochrome P450 2E1; cytochrome P450 family 2 subfamily E member 1; cytochrome P450 subfamily 2e1 (ethanol-inducible); cytochrome P450, 2e1, ethanol inducible; cytochrome P450, family 2, subfamily e, polypeptide 1; cytochrome P450, subfamily 2E, polypeptide 1; cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1; cytochrome P450-ALC; Cytochrome P450-J; cytochrome P450RLM6; flavoprotein-linked monooxygenase; microsomal monooxygenase; P450C2E; P450-J; P450RLM6; xenobiotic monooxygenase
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13106, 25086
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 5mg BSA and 0.05mg sodium azide, 0.05mg thimerosal
• Gene Accession No.: P05182, Q05421
• Gene Symbols: Cyp2e1
• Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of mouse CYP2E1 (94-112aa KNEFSGRGDIPVFQEYKNK).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG