CYP2J2 Mouse anti-Human, Clone: OTI5C5, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA525705
DescriptionCYP2J2 (cytochrome P450 2J2), also known as CPJ2, is a member of the cytochrome P450 protein superfamily. Localized to the ER (endoplasmic reticulum) and microsomal membranes, CYP2J2 is one of three cytochrome P450 enzymes that are responsible for metabolizing arachidonic acid to epoxyeicosatrienoic acids. Functioning via an NADPH-dependent olefin epoxidation, CYP2J2 epoxidizes endogenous cardiac arachidonic acid pools to four different isoforms of epoxyeicosatrienoic acid, all of which are important regulators of cardiovascular homeostasis and vascular tone. CYP2J2 is highly expressed in the heart with low levels of expression found in the liver, colon and kidneys. Up-regulation of CYP2J2 by a c-Jun responsive pathway is thought to promote the neoplastic phenotype of certain carcinoma cells, implicating CYP2J2 in carcinogenesis.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|CPJ2, CYPIIJ2, arachidonic acid epoxygenase, cytochrome P450 2J2, cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase) polypeptide 2, flavoprotein-linked monooxygenase, microsomal monooxygenase|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of CYP2J2 produced in HEK293T cell|
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