BioVision Inc Cytochrome P450 3A4 (CYP3A4) Activity Assay Kit (Fluorometric): Highly Sensitive; Includes human CYP3A4 - NADPH Reductase as positive control.
Manufacturer: BioVision Inc K701200
Cytochrome P450 3A4 (CYP3A4) Activity Assay Kit (Fluorometric): Cytochrome P450 3A4 (CYP3A4, EC 184.108.40.206) is a member of the cytochrome P450 monooxidase (CYP) family of microsomal xenobiotic metabolism enzymes. Inhibition of CYP3A4-mediated metabolism is a common cause of adverse drug/drug and drug/food interactions and toxicity.BioVision's CYP3A4 Activity Assay Kit enables rapid measurement of native or recombinant CYP3A4 activity in biological samples such as liver microsomes. The assay utilizes a non-fluorescent CYP3A4 substrate that is converted into a highly fluorescent metabolite detected in the visible range (Ex/Em = 535/587 nm), ensuring a high signal-to-background ratio with little interference by autofluorescence. CYP3A4 specific activity is calculated by running parallel reactions in the presence and absence of the potent inhibitor Ketoconazole and subtracting any residual activity detected with the inhibitor present. BioVision charges an Ice pack fee for each order.
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