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CYP4F3 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549617

Catalog No. PA549617

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Cytochrome P450 super family proteins are monooxygenases which catalyze multiple biochemical reactions involved in drug metabolism and synthesis of cholesterol, steroids and lipids. CYP4F3, a 60KDa protein, is a novel member of this family. It consists of a conserved heme-binding domain near the C-terminus and catalyzes the u-hydroxylation of LTB4. CYP4F3 is localized in the ER and plays a vital role in the inactivation of LTB4 and controlling inflammation. CYP4F3 exists in two functionally distinct isoforms: CYP4F3A, a neutrophil isoform, is particularly expressed in neutrophils and myeloid cells and catalyzes the microsomal u-hydroxylation of LTB4. It interacts with CD11b and myeloperoxidase on myeloid cells and regulates cellular development in bone marrow. CYP4F3B, a liver isoform, catalyzes the conversion of arachidonic acid to 20-HETE, a potent activator of PKC. Itrole hasbeen implicatedin cell proliferation, vascular tone and natriuresis.
Specifications

Specifications

CYP4F3
Polyclonal
PBS with 0.09% sodium azide
Q08477
Docosahexaenoic acid omega-hydroxylase CYP4F3, 20-hydroxyeicosatetraenoic acid synthase, 20-HETE synthase, 11413-, CYPIVF3, Cytochrome P450 4F3, Cytochrome P450-LTB-omega, Leukotriene-B(4) 20-monooxygenase 2, Leukotriene-B(4) omega-hydroxylase 2, CYP4F3, LTB4H
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
4051
Flow Cytometry, Western Blot
Unconjugated
CYP4F3
Liquid
CYP4F3
KLH conjugated synthetic peptide between 77-109 amino acids from the N-terminal region of human CYP4F3.
Ammonium sulfate precipitation
RUO
Antibody
Polyclonal
Human
Documents
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