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CYP4F3 Rabbit anti-Human, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 197011AP

Catalog No. 50-173-2498


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Description

Description

Cytochrome P450 super family proteins are monooxygenases which catalyze multiple biochemical reactions involved in drug metabolism and synthesis of cholesterol, steroids and lipids. CYP4F3, a 60 kDa protein, is a novel member of this family. It consists of a conserved heme-binding domain near the C-terminus and catalyzes the u-hydroxylation of LTB4. CYP4F3 is localized in the ER and plays a vital role in the inactivation of LTB4 and controlling inflammation. CYP4F3 exists in two functionally distinct isoforms: CYP4F3A, a neutrophil isoform, is particularly expressed in neutrophils and myeloid cells and catalyzes the microsomal u-hydroxylation of LTB4. It interacts with CD11b and myeloperoxidase on myeloid cells and regulates cellular development in bone marrow. CYP4F3B, a liver isoform, catalyzes the conversion of arachidonic acid to 20-HETE, a potent activator of PKC. Its role has been implicated in cell proliferation, vascular tone and natriuresis.
Specifications

Specifications

CYP4F3
0.46 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q08477
CPF3, CYP4F, CYP4F3, CYPIVF3, Cytochrome P450 4F3, Cytochrome P450 LTB omega, LTB4H
Rabbit
IgG
150 μL
-20°C
Primary
4051
Western Blot
Unconjugated
CYP4F3
Liquid
CYP4F3
Peptide
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Documents
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