CYR61 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA123143

Catalog No. PIPA123143

Description

PA1-23143 detects CYR61 in Human, Mouse and Rat samples. PA1-23143 has been successfully used in Western Blot procedures. PA1-23143 immunogen corresponds to Synthetic peptide from CYR61 (Human). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

CYR61 is a secreted, cysteine-rich, heparin-binding protein encoded by a growth factor inducible immediate-early gene. It promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion and appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA A, VEGA C, MMP1, MMP3, TIMP1, uPA, PAI 1 and integrins alpha 3 and alpha 5. Cyr61 mediated gene regulation is dependent on heparin binding. Down-regulates the expression of alpha-1 and alpha 2 subunits of collagen type 1. Promotes cell adhesion and adhesive signaling through integrin alpha 6/beta 1, cell migration through integrin alpha v/beta 5 and cell proliferation through integrin alpha v/beta 3.

Specifications

• Antigen: CYR61
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene Accession No.: O00622, P18406, Q9ES72
• Gene Symbols: CYR61
• Immunogen: Synthetic peptide from CYR61 (Human)
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Gene: CYR61
• Gene Alias: CCN1, GIG1, IGFBP10
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 16007, 3491, 83476
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid